Igg4-Related Disorder and Endocrine Diseases: A Review of the Literature
نویسندگان
چکیده
IgG4-related disorders (IgG4-RD) are a new entity of multi-organ disorders that share common fibro-inflammatory histopathologic characteristics and elevated IgG4 levels in serum and tissue. Autoimmune pancreatitis and Mikulicz syndrome are major entities, however many syndromes are part of IgG4-RD including eosinophilic angiocentric fibrosis, fibrosing mediastinitis, hypertrophic pachymeningitis, inflammatory pseudotumour, multifocal fibrosclerosis (commonly affecting the orbits, thyroid gland, retroperitoneum, mediastinum, and other tissues and organs), periaortitis and peri-arteritis, inflammatory aortic aneurysm, retroperitoneal fibrosis (Ormond’s disease), Riedel’s thyroiditis, and sclerosing mesenteritis. In this review we detail the link between IgG4-RD and endocrine disorders and then examine the link between diabetes and IgG4-RD. We study the increased risk of IgG4-RD after using dulaglutide. We concluded that IgG4-RD should be suspected in patients with progressive thyroiditis with mass effect and very high antibody titers. The relationship between IgG4-RD and diabetes is still controversial. Igg4-Related Disorder and Endocrine Diseases: A Review of the Literature Alaaeldin M Bashier1*, Ghita Harifi2 and Elamin I Abdelgadir3 1Endocrine Division, Medical department, Dubai Hospital, UAE 2Rheumatology division, Dubai Hospital, Dubai UAE 3Endocrine division, Dubai Hospital, Dubai, UAE *Corresponding author: Alaaeldin M Bashier, Endocrine Division, Medical department, Dubai Hospital, P.O. Box 94132, UAE, Tel : +971554154445; E-mail: [email protected] Received October 28, 2015; Accepted December 05, 2015; Published December 10, 2015 Citation: Bashier AM, Harifi G, Abdelgadir EI (2015) Igg4-Related Disorder and Endocrine Diseases: A Review of the Literature. J Diabetes Metab 6: 631. doi:10.4172/2155-6156.1000631 Copyright: © 2015 Bashier AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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